Journal of Molecular Biology
Changes in size and secondary structure of the ribosomal transcription unit during vertebrate evolution☆
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2019, Trends in GeneticsCitation Excerpt :This instability, combined with the importance of the rDNA loci for cell functionality, demands special attention to maintain these loci. Despite its critical importance, rDNA has escaped genomics-era analysis due to the difficulty in sequencing the loci, because of its repetitiveness and large unit size (8–13 kb for each repeat [2–6]), limiting the ability to obtain precise copy number information through genome sequencing. Still, gross assessments of rDNA copy number have led to a widely accepted notion that rDNA loci are dynamic and copy number varies considerably between individuals within a species, and even likely between cells within a single organism [7–11].
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This work has been supported by the Swiss National Science Foundation grant no. 3.872.72.